Quizartinib
Population pharmacokinetic analysis of datopotamab deruxtecan (Dato-DXd), a TROP2-Directed Antibody-Drug Conjugate, in Patients with advanced solid tumors
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Publications
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T-DXd
Breast Cancer
Effectiveness of additional risk minimization measures related to interstitial lung disease/pneumonitis with trastuzumab deruxtecan treatment of breast cancer in European Countries: results and learnings from a post-authorization safety survey among physicians
Wientzek-Fleischmann A, Stellmacher U, Beyerlein E, Gohlke A, Ehlken B.
Pharmacoepidemiol Drug Saf. 2025;34(9):e70206. doi: 10.1002/pds.70206.
Valemetostat
Hematology
Population pharmacokinetics of valemetostat and exposure–response analyses of efficacy and safety in patients with relapsed/refractory peripheral T–cell lymphoma
Inoue H, Wang X, Garcia R, et al.
J Clin Pharmacol. 2025. doi: 10.1002/jcph.70100.
Quizartinib
Hematology
QuANTUM-First: Clinical validation of the LeukoStrat companion diagnostic for the selection of patients with acute myeloid leukemia harboring FMS-like tyrosine kinase 3-internal tandem duplications for treatment with quizartinib
Connolly Rohrbach JE, Chang KCN, Karnoub M, et el.
Arch Pathol Lab Med. 2025. doi: 10.5858/arpa.2024-0449-OA.
Pexidartinib
Hematology
A phase 3 study of the efficacy and safety of pexidartinib in East Asian Patients with Tenosynovial Giant Cell Tumor
Xu H, Wu PK, Ye Z, et al.
Oncol Ther. 2025. doi: 10.1007/s40487-025-00365-z.
Edoxaban
Cardiovascular - AF
An efficient approach for detecting atrial fibrillation in ischemic stroke patients using a wearable device: a prospective multicenter substudy of the STABLED trial
Saito T, Nishiyama Y, Otsuka T, et al.
Front Neurol. 2025;16:1560495. doi: 10.3389/fneur.2025.1560495.
T-DXd
Gastric Cancer
Trastuzumab deruxtecan in patients from China with previously treated human epidermal growth factor receptor 2-positive locally advanced/metastatic gastric or gastroesophageal junction adenocarcinoma (DESTINY-Gastric06): Results from a single-arm, multicenter, phase 2 trial
Peng Z, Chen P, Lu J, et al.
EClinicalMedicine. 2025;87:103404. doi: 10.1016/j.eclinm.2025.103404.
T-DXd
Breast Cancer
A Global Ring Study: Concordance between Ventana PATHWAY anti-HER2/neu (4B5) Companion Diagnostic Assay and comparators in detecting HER2-low breast cancer
Schildhaus HU, Badve S, D'Arrigo C, et al.
Mod Pathol. 2025:100867. doi: 10.1016/j.modpat.2025.100867.
T-DXd
Breast Cancer
Lung Cancer
Other/Multi
Pooled analysis of trastuzumab deruxtecan retreatment after recovery from grade 1 interstitial lung disease/pneumonitis
Rugo HS, Tokunaga E, Iwata H, et al.
Ann Oncol. 2025:S0923-7534(25)00912-3.
T-DXd
Breast Cancer
Effectiveness of post-trastuzumab deruxtecan treatments and incidence of interstitial lung disease in HER2-positive metastatic breast cancer: A real-world, observational cohort study
Nozawa K, Iwata H, Mukohara T, et al.
ESMO Open. 2025;10(8):105511. doi: 10.1016/j.esmoop.2025.105511.
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