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Information about pipeline products

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Quizartinib
Hematology
Safety and pharmacokinetics of quizartinib combination therapy with standard induction and consolidation chemotherapy in patients with newly diagnosed acute myeloid leukemia: Results from two phase 1 trials in Japan and China.
Qi J, Choi I, Ota S, et al.
Clin Pharmacol Drug Dev. 2024;13(5):560-571.
T-DXd
Other/Multi
Unveiling the intra-tumor fate of trastuzumab deruxtecan in a xenograft model to support its mechanism of action
Nagai Y, Oitate M, Shibayama T, Takakusa H, Watanabe N
Drug Metab Pharmacokinet. 2024;56:101001.
T-DXd
Breast Cancer
Neoadjuvant trastuzumab deruxtecan (T-DXd) with response-directed definitive therapy in early stage HER2-positive breast cancer: A phase II study protocol (SHAMROCK study)
Dowling GP, Toomey S, Bredin P, et al.
BMC Cancer. 2024;24(1):91.
Other/Multi
Lung Cancer
HER2-mutant advanced and/or metastatic non-small-cell lung cancer: A US electronic health records database analysis of clinical characteristics, treatment practice patterns, and outcomes
Waliany S, Neal JW, Engel-Nitz N, et al.
Clin Lung Cancer. 2024;25(4):319-328.
T-DXd
Other/Multi
Trastuzumab deruxtecan in patients with human epidermal growth factor receptor 2-expressing salivary gland carcinoma: A pooled analysis of two phase I studies
Takahashi S, Bando H, Kinoshita I, et al.
Jpn J Clin Oncol. 2024;54(4):434-443.
Edoxaban
Cardiovascular - AF
Clinical outcomes and anticoagulation therapy in elderly non-valvular atrial fibrillation and heart failure patients
Ikeda S, Hiasa K-I, Inoue H, et al.
ESC Heart Fail. 2024;11(2):902-913.
Edoxaban
Cardiovascular - VTE
Risk factors for bleeding events in Japanese patients with advanced lung cancer: Data from the Rising-VTE/NEJ037 Study
Kawakado K, Tsubata Y, Hotta T, et al.
Cancers. 2024;16(2):301.
Edoxaban
Cardiovascular - VTE
Prevention of symptomatic pulmonary embolism for gynecologic malignancies with preoperative asymptomatic venous thromboembolism: GOTIC-VTE trial
Takahashi Y, Fujiwara H, Yamamoto K, et al.
J Gynecol Oncol. 2024;35(4):e37.
Edoxaban
Cardiovascular - AF
Treatment satisfaction and convenience for patients with atrial fibrillation on edoxaban or vitamin K antagonists after transcatheter aortic valve replacement: A post hoc analysis from the ENVISAGE-TAVI AF trial
Hengstenberg C, Van Mieghem NM, Wang R, et al.
Am J Cardiol. 2023;209:P212-219.
Edoxaban
Cardiovascular - AF Cardiovascular - VTE
Management of edoxaban therapy and clinical outcomes in patients undergoing major or nonmajor surgery: A subanalysis of the EMIT-AF/VTE study
von Heymann C, Unverdorben M, Colonna P, et al.
Thromb J. 2023;21(1):124.
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