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Information about pipeline products

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T-DXd
Gastric Cancer
Trastuzumab deruxtecan in anti-human epidermal growth factor receptor 2 treatment-naive patients with human epidermal growth factor receptor 2-low gastric or gastroesophageal junction adenocarcinoma: Exploratory cohort results in a phase II trial
Yamaguchi K, Bang YJ, Iwasa S, et al.
J Clin Oncol. 2023;41(4):816-825.
Edoxaban
Cardiovascular - AF Cardiovascular - VTE
Edoxaban in cardiovascular medicine from scientific evidence to clinical practice
Baran Budak A, Gencpinar T, Dogan E, Totan S, Akay HT.
Turk J Vasc Surg. 2022;31(3):195-206.
T-DXd
Breast Cancer
Effect of trastuzumab deruxtecan on QT/QTC interval and pharmacokinetics in HER2-positive or HER2-low metastatic/unresectable breast cancer
Shimomura A, Takano T, Takahashi S, et al.
Clin Pharmacol and Ther. 2023;113(1):160-169.
HER3-DXd
Breast Cancer Colorectal Cancer Lung Cancer
Population pharmacokinetics of patritumab deruxtecan in patients with solid tumors
Lu Y, Shimizu S, Sawamura R, et al.
J Clin Pharmacol. 2023;63(1):77-90.
Pexidartinib
Other/Multi
Pexidartinib provides modest pain relief in patients with tenosynovial giant cell tumor: Results from ENLIVEN
Healey JH, Tap WD, Gelhorn HL, et al.
Clin Orthop and Relat Res. 2023;481(1):107-116.
T-DXd
Breast Cancer Colorectal Cancer Gastric Cancer Lung Cancer Other/Multi
Pooled analysis of drug-related interstitial lung disease and/or pneumonitis in nine trastuzumab deruxtecan monotherapy studies
Powell CA, Modi S, Iwata H, et al.
ESMO Open. 2022;7(4):100554.
T-DXd
Breast Cancer
Trastuzumab deruxtecan in previously treated HER2-low advanced breast cancer.
Modi S, Jacot W, Yamashita T, et al.
N Engl J Med. 2022;387(1):9-20.
T-DXd
Breast Cancer
Trastuzumab deruxtecan versus trastuzumab emtansine for breast cancer
Cortes J, Kim SB, Chung WP, et al.
N Engl J Med. 2022;386(12):1143-1154.
Pexidartinib
Other/Multi
Results from phase I extension study assessing pexidartinib treatment in six cohorts with solid tumors including TGCT, and abnormal CSF1 transcripts in TGCT
Tap WD, Singh AS, Anthony SP, et al.
Clin Cancer Res. 2022;28(2):298-307.
HER3-DXd
Lung Cancer
Efficacy and safety of patritumab deruxtecan (HER3-DXd) in EGFR inhibitor-resistant, EGFR-mutated non-small cell lung cancer
Janne PA, Baik C, Su WC, et al.
Cancer Discov. 2022;12(1):74-89.
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