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Information about pipeline products

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Quizartinib
Hematology
Quizartinib plus chemotherapy in newly diagnosed patients with FLT3-internal-tandem-duplication-positive acute myeloid leukaemia (QuANTUM-First): A randomised, double-blind, placebo-controlled, phase 3 trial
Erba HP, Montesinos P, Kim HJ, et al.
Lancet. 2023;401(10388):1571-1583.
T-DXd
Breast Cancer
Trastuzumab deruxtecan versus treatment of physician's choice in patients with HER2-positive metastatic breast cancer (DESTINY-Breast02): A randomised, open-label, multicentre, phase 3 trial
André F, Hee Park Y, Kim SB, et al.
Lancet. 2023;401(10390):1773-1785.
Pexidartinib
Other/Multi
Dosing recommendation based on the effects of different meal types on pexidartinib pharmacokinetics in healthy subjects: Implementation of model-informed drug development strategy
Zahir H, Yin O, Hsu C, et al.
Clin Pharmacol Drug Dev. 2023;12(5):475-483.
Valemetostat
Hematology
An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma
Izutsu K, Makita S, Nosaka K, et al.
Blood. 2023;141(10):1159-1168.
Edoxaban
Cardiovascular - AF
Clinical phenotypes of older adults with non-valvular atrial fibrillation not treated with oral anticoagulants by hierarchical cluster analysis in the ANAFIE registry
Suzuki S, Yamashita T, Akao M, et al.
PLoS One. 2023;18(2):e0280753.
HER3-DXd
Other/Multi
Changes in HER3 expression profiles between primary and recurrent gynecological cancers
Kojima Y, Sudo K, Yoshida H, et al.
Kojima et al. Cancer Cell International (2023) 23:18 https://doi.org/10.1186/s12935-022-02844-z
HER3-DXd
Other/Multi
Quantitative analysis of drug distribution in heterogeneous tissues using dual-stacking capillary electrophoresis-mass spectrometry
Koganemaru S, Kawai T, Fuchigami H, et al.
Br J Pharmacol. 2023;180(6):762-774.
T-DXd
Breast Cancer
Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: Updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial
Hurvitz SA, Hegg R, Chung W-P, et al.
Lancet. 2023;401(10371):105-117.
T-DXd
Breast Cancer
Trastuzumab deruxtecan in HER2-positive metastatic breast cancer patients with brain metastases: A DESTINY-Breast01 subgroup analysis
Jerusalem G, Park YH, Yamashita T, et al.
Cancer Discov. 2022;12(12):2754–2762.
Edoxaban
Cardiovascular - VTE
Effect of edoxaban, F-Xa-directed oral anticoagulant on spontaneous thrombolytic activity in Apoe-/- and Ldlr-/- double knockout mice
Hyodo K, Ohta N, Ishii H, Yamashita T.
Int J Clin Cardiol. 2022;9(6):1410272.
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