T-DXd
Breast Cancer
Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: A phase 3b/4 trial
Harbeck N, Ciruelos E, Jerusalem G, et al.
Nat Med. 2024;30(12):3780. doi: 10.1038/s41591-024-03349-0.
Dato-DXd
Breast Cancer
Datopotamab deruxtecan versus chemotherapy in previously treated inoperable/metastatic hormone receptor-positive human epidermal growth factor receptor 2-negative breast cancer: Primary results from TROPION-Breast01
Bardia A, Jhaveri K, Im S-A, et al.
J Clin Oncol. 2025;43(3):285-296. doi: 10.1200/JCO.24.00920.
Edoxaban
Cardiovascular - AF
Cardiovascular - VTE
Exposure matching-based pediatric dose selection for drugs with renal excretion - lessons learned from pediatric development of direct oral anticoagulants
Zou P, Leil TA
Clin Pharmacol Ther. 2024;116(5):1174-1187. doi: 10.1002/cpt.3396.
T-DXd
Breast Cancer
Global study on the accuracy of human epidermal growth factor receptor 2-low diagnosis in breast cancer
Rüschoff J, Penner A, Ellis IO, et al.
Arch Pathol Lab Med. 2024. doi: 10.5858/arpa.2024-0052-OA. Epub ahead of print.
T-DXd
Colorectal Cancer
Trastuzumab deruxtecan in patients with HER2-positive advanced colorectal cancer (DESTINY-CRC02): Primary results from a multicentre, randomised, phase 2 trial
Raghav K, Siena S, Takashima A, et al.
T-DXd
Tumor-agnostic
Other/Multi
Trastuzumab deruxtecan in human epidermal growth factor receptor 2-expressing biliary tract cancer (HERB; NCCH1805): A multicenter, single-arm, phase II trial
Ohba A, Morizane C, Kawamoto Y, et al.
J Clin Oncol. 2024:JCO2302010. doi: 10.1200/JCO.23.02010. Epub ahead of print.
HER3-DXd
Lung Cancer
Real-world treatment patterns and clinical outcomes among patients with metastatic or unresectable EGFR-mutated non-small cell lung cancer previously treated with osimertinib and platinum-based chemotherapy
Patel J, Meng J, Le H, et al.
Adv Ther. 2024;41(8):3299-3315. doi: 10.1007/s12325-024-02936-4.
Valemetostat
Tumor-agnostic
Other/Multi
Population pharmacokinetics of total and unbound valemetostat and platelet dynamics in healthy volunteers and patients with non-Hodgkin lymphoma
Fukae M, Baron K, Tachibana M, et al.
CPT Pharmacometrics Syst Pharmacol. 2024. doi: 10.1002/psp4.13201. Epub ahead of print.
Edoxaban
Cardiovascular - AF
Patient outcomes in very elderly patients with non-valvular atrial fibrillation - ANAFIE Registry -
Suzuki S, Yamashita T, Akao M, et al.
Circ Rep. 2024;6(8):283-293. doi: 10.1253/circrep.CR-24-0061.
Edoxaban
Lung Cancer
Cardiovascular - VTE
Venous thromboembolism in patients undergoing surgery for lung cancer: A post hoc analysis of the Cancer-VTE Registry
Kawachi R, Okano T, Awano N, et al.
Jpn J Clin Oncol. 2024:hyae090. doi: 10.1093/jjco/hyae090. Epub ahead of print.