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Dato-DXd
Lung Cancer
Datopotamab deruxtecan versus docetaxel for previously treated advanced or metastatic non-small cell lung cancer: The randomized, open-label phase III TROPION-Lung01 study
Ahn M-J, Tanaka K, Paz-Ares L, et al.
J Clin Oncol. 2025;43(3):260-272. doi: 10.1200/JCO-24-01544.
T-DXd
Lung Cancer
Analytical and clinical validation of the plasma-based Guardant360 CDx test for assessing HER2 (ERBB2) mutation status in patients with non-small-cell lung cancer for treatment with trastuzumab deruxtecan in DESTINY-Lung01/02
Qi Z, Tokuhiro S, Odegaard JI, et al.
J Mol Diagn. 2025;27(2):119-129.
T-DXd
Breast Cancer
Quality-adjusted time without symptoms or toxicity analysis of trastuzumab deruxtecan versus trastuzumab emtansine in HER2-positive metastatic breast cancer patients based on secondary use of the DESTINY-Breast03 trial
Dennis N, Dunton K, Livings C,et al.
Eur J Cancer. 2024;217:115192. doi: 10.1016/j.ejca.2024.115192
T-DXd
Breast Cancer
A randomized, double-blind, placebo-controlled phase II study of olanzapine-based prophylactic antiemetic therapy for delayed and persistent nausea and vomiting in patients with HER2-positive or HER2-low breast cancer treated with trastuzumab deruxtecan: ERICA study (WJOG14320B)
Sakai H, Tsurutani J, Ozaki Y, et al.
Ann Oncol. 2025;36(1):31-42. doi: 10.1016/j.annonc.2024.09.001.
T-DXd
Breast Cancer
Trastuzumab deruxtecan after endocrine therapy in metastatic breast cancer
Bardia A, Hu X, Dent R, et al.
N Engl J Med. 2024;391(22):2110-2122. doi: 10.1056/NEJMoa2407086
T-DXd
Breast Cancer
Datopotamab-deruxtecan plus durvalumab in early-stage breast cancer: The sequential multiple assignment randomized I-SPY2.2 phase 2 trial
Shatsky RA, Trivedi MS, Yau C, et al.
Nat Med. 2024;30(12):3737-3747. doi: 10.1038/s41591-024-03267-1.
T-DXd
Breast Cancer
A pooled analysis of trastuzumab deruxtecan in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer with brain metastases
André F, Cortés J, Curigliano G, et al.
Ann Oncol. 2024;35(12):1169-1180. doi: 10.1016/j.annonc.2024.08.2347.
T-DXd
Breast Cancer
Trastuzumab deruxtecan for the treatment of patients with HER2-positive breast cancer with brain and/or leptomeningeal metastases: an updated overall survival analysis using data from a multicenter retrospective study (ROSET-BM)
Nakayama T, Niikura N, Yamanaka T, et al.
Breast Cancer. 2024;31(6):1184. doi: 10.1007/s12282-024-01632-z.
T-DXd
Tumor-agnostic
Efficacy of trastuzumab deruxtecan in HER2-expressing solid tumors by enrollment HER2 IHC status: Post hoc analysis of DESTINY-PanTumor02
Oaknin A, Lee J-Y, Makker V, et al.
Adv Ther. 2024;41(11):4125-4139. doi: 10.1007/s12325-024-02975-x.
Other/Multi
Other/Multi
Decoding clinical trial jargon: Helping people understand the efficacy end points used in cancer trials
Henley M, DeCotiis G, FitzGibbon H, Singhi EK
Future Oncol. 2025;21(1):11-14. doi: 10.1080/14796694.2024.2433411.
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