Edoxaban
Cardiovascular - AF
Ischemic and bleeding events after early initiation of direct oral anticoagulants for acute intracranial hemorrhage with non-valvular atrial fibrillation - A multicenter prospective registry.
Koga M, Toyoda K, Iguchi Y, et al.
Circ J. 2026 Feb 25. doi: 10.1253/circj.CJ-25-0791.
HER3-DXd
Other/Multi
The impact of HER3 dynamics altered by HER3-DXd alone and in combination with driver oncogene inhibitors on HER3-DXd efficacy
Komatsu N, Sato S, Nakamura R, et al.
Int J Mol Sci. 2026 Feb 17;27(4):1930. doi: 10.3390/ijms27041930.
Dato-DXd
Breast Cancer
Optimal dosage justification for datopotamab deruxtecan in HR-positive/HER2-negative breast cancer through model-informed drug development approaches
Tang Z, Lim K, Jiang Y, et al.
Clin Transl Sci. 2026 Feb;19(2):e70493. doi: 10.1111/cts.70493.
T-DXd
Lung Cancer
Trastuzumab deruxtecan in HER2-mutant metastatic non-small-cell lung cancer: A plain language summary of the DESTINY-Lung02 study
Jänne PA.
Future Oncol. 2026 Mar;22(6):659-670. doi: 10.1080/14796694.2025.2598216.
T-DXd
Breast Cancer
Comparative efficacy of trastuzumab deruxtecan versus guideline-recommended treatments for 2L+ unresectable locally advanced or metastatic HER2-mutant non-small cell lung cancer: A systematic review and indirect treatment comparison
Cappuzzo F, Zhang L, Dunton K, Dennis N, Le Nouveau P, Nevière A, Gauthier A.
Front Oncol. 2026 Feb 13;15:1708245. doi: 10.3389/fonc.2025.1708245.
Dato-DXd
Lung Cancer
TROPION-Lung10: A phase 3 study of datopotamab deruxtecan and rilvegostomig in patients with treatment-naïve locally advanced or metastatic nonsquamous non-small cell lung cancer with high PD-L1 expression and without actionable genomic alterations
Newsom-Davis T, Melosky B, Heist RS, et al.
Front Oncol. 2026 Feb 11;16:1804953. doi: 10.3389/fonc.2026.1804953.
Quizartinib
Hematology
FLT3-ITD measurable residual disease from the QuANTUM-First trial
Levis MJ, Erba HP, Montesinos P, et al.
Blood Adv. 2026 Feb 10;10(3):917-928. doi: 10.1182/bloodadvances.2025016444.
Edoxaban
Cardiovascular - AF
Major bleeding risk assessment with atrial fibrillation post-TAVR: The HARHP score results from ENVISAGE-TAVI AF
Dangas GD, Unverdorben M, Hengstenberg C, et al.
JACC Cardiovasc Interv. 2026 Feb 9;19(3):359-368. doi: 10.1016/j.jcin.2025.11.028.
T-DXd
Breast Cancer
Real-world treatment patterns and outcomes in HER2-low, HR+ metastatic breast cancer patients previously treated with endocrine therapy in the United States
Modi S, Byng D, Zhang S, et al.
Breast. 2026 Apr;86:104721. doi: 10.1016/j.breast.2026.104721.
T-DXd
Breast Cancer
Safety and effectiveness of post-trastuzumab deruxtecan regimens in patients with HER2-positive metastatic breast cancer who discontinued trastuzumab deruxtecan due to interstitial lung disease
Tsurutani J, Nozawa K, Mukohara T, et al.
Breast. 2026 Apr;86:104722. doi: 10.1016/j.breast.2026.104722.